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Mushroom Extracts

The science behind lion's mane, reishi, and turkey tail โ€” what clinical trials actually show about cognition, immune health, and stress adaptation.

400+
PubMed Studies on Reishi
3
Mushrooms Reviewed
2023
Latest Trial Data
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Lion's Mane & NGF

Hericenones and erinacines stimulate Nerve Growth Factor โ€” the 2009 Mori RCT showed improved cognitive scores over 16 weeks.

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Turkey Tail & Immunity

PSK (polysaccharide-K) approved in Japan since 1977. 2012 NIH-funded trial showed significant NK cell and CD8+ T cell increases.

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Reishi & Adaptogenesis

Triterpenoids modulate the stress response. GABA-pathway activity may explain reishi's sleep and anxiety effects.

Featured Article

Lion's mane mushroom cognitive health

All Mushroom Extract Articles

Lion's mane
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Lion's Mane: The NGF Research for Adults Over 50

NGF stimulation via hericenones/erinacines. 2009 Mori RCT, 2023 Australian data, anxiety/depression, fruiting body vs mycelium quality.

June 2026 ยท 8 min
Reishi mushroom
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Reishi Mushroom: The Adaptogen With 400+ Studies

Triterpenoids, beta-glucans, and adenosine. NK cell immunity trial, gut-brain axis sleep mechanism, neurasthenia fatigue data.

June 2026 ยท 7 min
Turkey tail mushroom
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Turkey Tail: PSK, Immune Support, and the NIH-Funded Trial

PSK approved in Japan since 1977. 2012 NIH breast cancer survivor trial, 2014 UC Davis gut microbiome study, TLR/Dectin-1 mechanism.

June 2026 ยท 7 min
Quality Note: All mushroom extract articles address the critical quality distinction between fruiting body extracts (higher beta-glucan content, more studied) and mycelium-on-grain products (often mostly grain starch). This distinction is rarely explained in supplement marketing but is essential for evaluating product effectiveness.