The science behind lion's mane, reishi, and turkey tail โ what clinical trials actually show about cognition, immune health, and stress adaptation.
Hericenones and erinacines stimulate Nerve Growth Factor โ the 2009 Mori RCT showed improved cognitive scores over 16 weeks.
PSK (polysaccharide-K) approved in Japan since 1977. 2012 NIH-funded trial showed significant NK cell and CD8+ T cell increases.
Triterpenoids modulate the stress response. GABA-pathway activity may explain reishi's sleep and anxiety effects.
Lion's mane stimulates Nerve Growth Factor via hericenones and erinacines. The landmark 2009 Mori trial, 2020 and 2023 Australian follow-ups, anxiety and depression data, and the critical quality distinction between fruiting body and mycelium-on-grain products.
Read Article โNGF stimulation via hericenones/erinacines. 2009 Mori RCT, 2023 Australian data, anxiety/depression, fruiting body vs mycelium quality.
Triterpenoids, beta-glucans, and adenosine. NK cell immunity trial, gut-brain axis sleep mechanism, neurasthenia fatigue data.
PSK approved in Japan since 1977. 2012 NIH breast cancer survivor trial, 2014 UC Davis gut microbiome study, TLR/Dectin-1 mechanism.